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Johns Hopkins University logoProgram in Molecular Biophysics
Gregory ChirikjianChirikjian Lab

Greg Chirikjian

Professor
Department of Mechanical Engineering
Whiting School of Engineering


B.S., B.A., M.S.E. 1988, Johns Hopkins University
Ph.D. 1992, California Institute of Technology


gregc@jhu.edu

117 CSEB
3400 N. Charles Street
Baltimore, MD 21218

Office: 410-516-7127

 

School of Engineering logo

  • Computational structural biology (in particular, computational mechanics of large proteins)
  • Conformational statistics of biological macromolecules
  • Developed theory for 'hyper-redundant' (snakelike) robot motion planning
  •  Designs and builds hyper-redundant robotic manipulator arms
  •  Applied mathematics (applications of group theory in engineering)
  •  Self-replicating robotic systems

Selected Publications
Wolfe, K.C., and G.S. Chirikjian. (2012) Quantitative comparison of conformational ensembles. Entropy 14:213-232.

Chirikjian, G.S. (2011) Modeling loop entropy. Methods Enzymol. Part C: 487:101-130.

Chirikjian, G.S. (2010) Group theory and biomolecular conformation, l.: Mathematical and computational models. J. Phys. Condens. Matter 22:323103.

Schuyler, A.D., R.L. Jernigan, P.K. Qasba, B. Ramakrishnan, and G.S. Chirikjian. (2009) Iterative cluster-NMA (icNMA): A tool for generating conformational transitions in proteins. Proteins 74:760-776.

Chirikjian, G.S. (2008) The stochastic elastica and excluded-volume perturbations of DNA. Int. J. Non. Mech. 43:1108-1120.

Jeong, J., E. Lattman, and G.S. Chirikjian. (2006) A method for finding candidate conformations for molecular replacement using relative rotation between domains of a known structure. Acta Crstallographica D D62:398-409.

Zhou, Y., and G.S. Chirikjian. (2006) Conformational statistics of semi-flexible macromolecular chains with internal joints. Macromolecules 39:1950-1960.

Lee, S., and G.S. Chirikjian. (2004) Interhelical angle and distance preferences in globular proteins. Biophys. J. 286:1105-17.

Kim, M.K., R.L. Jernigan, and G.S. Chirikjian. (2003) An elastic network model of HK97 capsid maturation. J. Struct. Biol. 143:107-117.

Kim, M.K., R.L. Jernigan, and G.S. Chirikjian. (2002) Efficient generation of feasible pathways for protein conformational transitions. Biophys. J. 83:1620-30.

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