Professor Department of Mechanical Engineering Whiting School of Engineering B.S., B.A., M.S.E. 1988, Johns Hopkins University Ph.D. 1992, California Institute of Technology
gregc@jhu.edu 117 CSEB 3400 N. Charles Street Baltimore, MD 21218 Office: 410-516-7127
| - Computational structural biology (in particular, computational mechanics of large proteins)
- Conformational statistics of biological macromolecules
- Developed theory for 'hyper-redundant' (snakelike) robot motion planning
- Designs and builds hyper-redundant robotic manipulator arms
- Applied mathematics (applications of group theory in engineering)
- Self-replicating robotic systems
Selected Publications Wolfe, K.C., and G.S. Chirikjian. (2012) Quantitative comparison of conformational ensembles. *Entropy* 14:213-232. Chirikjian, G.S. (2011) Modeling loop entropy. *Methods Enzymol. Part C:* 487:101-130. Chirikjian, G.S. (2010) Group theory and biomolecular conformation, l.: Mathematical and computational models. *J. Phys. Condens. Matter* 22:323103. Schuyler, A.D., R.L. Jernigan, P.K. Qasba, B. Ramakrishnan, and G.S. Chirikjian. (2009) Iterative cluster-NMA (icNMA): A tool for generating conformational transitions in proteins. *Proteins* 74:760-776. Chirikjian, G.S. (2008) The stochastic elastica and excluded-volume perturbations of DNA. *Int. J.* *Non. Mech.* 43:1108-1120. Jeong, J., E. Lattman, and G.S. Chirikjian. (2006) A method for finding candidate conformations for molecular replacement using relative rotation between domains of a known structure. *Acta Crstallographica D* D62:398-409. Zhou, Y., and G.S. Chirikjian. (2006) Conformational statistics of semi-flexible macromolecular chains with internal joints. *Macromolecules* 39:1950-1960. Lee, S., and G.S. Chirikjian. (2004) Interhelical angle and distance preferences in globular proteins. *Biophys. J.* 286:1105-17. Kim, M.K., R.L. Jernigan, and G.S. Chirikjian. (2003) An elastic network model of HK97 capsid maturation. *J. Struct. Biol.* 143:107-117. Kim, M.K., R.L. Jernigan, and G.S. Chirikjian. (2002) Efficient generation of feasible pathways for protein conformational transitions. *Biophys. J.* 83:1620-30. |