Johns Hopkins UniversityProgram in Molecular Biophysics
Gregory ChirikjianChirikjian Lab

Greg Chirikjian

Professor
Department of Mechanical Engineering
Whiting School of Engineering


B.S., B.A., M.S.E. 1988, Johns Hopkins University
Ph.D. 1992, California Institute of Technology


gregc@jhu.edu

117 CSEB
3400 N. Charles Street
Baltimore, MD 21218

Office: 410-516-7127

  • Computational structural biology (in particular, computational mechanics of large proteins)
  • Conformational statistics of biological macromolecules
  • Developed theory for 'hyper-redundant' (snakelike) robot motion planning
  •  Designs and builds hyper-redundant robotic manipulator arms
  •  Applied mathematics (applications of group theory in engineering)
  •  Self-replicating robotic systems

Selected Publications
Skliros, A., and G.S. Chirikjian. (2007) Torsional random-walk statistics on lattices using convolution on crystallographic motion groups. Polymer 48:2155-2173.

Jeong, J., E. Lattman, and G.S. Chirikjian. (2006) A method for finding candidate conformations for molecular replacement using relative rotation between domains of a known structure. Acta Crstallographica D D62:398-409.

Zhou, Y., and G.S. Chirikjian. (2006) Conformational statistics of semi-flexible macromolecular chains with internal joints. Macromolecules 39:1950-1960.

Hastings, W.A., Y. Yingling, G.S. Chirikjian, and B.A. Shapiro. (2006) Structural and dynamical classification of RNA single-base bulges for nanostructure design. J. Comput. Theor. Nanosci. 3:63-77 FEB

Schuyler, A.D., G.S. Chirikjian, J.Q. Lu and H.T. Johnson. (2005) Random-walk statistics in moment-based O(N) tight binding and applications in carbon nanotubes. Phys. Rev. 71(4 Pt 2):046701.

Lee, S., and G.S. Chirikjian. (2005) Pose analysis of alpha-carbons in proteins. Int. J. Robot. Res. 24:183-210.

Lee, S., and G.S. Chirikjian. (2004) Interhelical angle and distance preferences in globular proteins. Biophys. J. 286:1105-17.

Schuyler, A.D., and G.S. Chirikjian. (2004) Normal mode analysis of proteins: a comparison of rigid cluster modes with C(alpha) coarse graining. J. Mol. Graph. Model. 22:183-93.

Kim, M.K., W. Li, B.A. Shapiro, and G.S. Chirikjian. (2003) A comparison between elastic network interpolation and MD simulation of 16S ribosomal RNA. J. Biomol. Struct. Dyn. 21:395-405.

Kim, M.K., R.L. Jernigan, and G.S. Chirikjian. (2003) An elastic network model of HK97 capsid maturation. J. Struct. Biol. 143:107-117.

Kim, M.K., R.L. Jernigan, and G.S. Chirikjian. (2002) Elastic models of conformational transitions in macromolecules. J. Mol. Graph. Model. 21:151-160.

Kim, M.K., R.L. Jernigan, and G.S. Chirikjian. (2002) Efficient generation of feasible pathways for protein conformational transitions. Biophys. J. 83:1620-30.

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