Class of 2005
jfriedman@jhu.edu | B.S. Biochemistry & Molecular Biology, Penn State University
Research
Biomolecules have highly dynamic structures that undergo motions over many different time scales that may be essential to their biological functions. In the Stivers laboratory we are interested in the roles of DNA and enzyme dynamics to the recognition of specific damaged sites in DNA by DNA repair enzymes. NMR spectroscopy is perhaps the preeminent technique for investigating dynamic motions over a great range of time scales. My project involves the use of NMR dynamic methods to investigate the recognition of uracil in DNA by the powerful DNA repair enzyme uracil DNA glycosylase.
Publications
|
