Class of 2003
sarah_mitchell@jhu.edu | B.A. Biochemistry, University of Pennsylvania
Research
The Lorsch lab is interested in the molecular mechanisms of eukaryotic translation initiation. I am investigating the steps of mRNA preparation and recruitment of the small ribosomal subunit to the mRNA.
Publications
Acker, M.G., S.E. Kolitz, S.F. Mitchell, J.S. Nanda, and J.R. Lorsch. (2007) Reconstitution of yeast translation initiation. Methods Enzymol. 430:111-145.
Cheung, Y.N., D. Maag, S.F. Mitchell, C.A. Fekete, M.A. Algire, J.E. Takacs, N. Shirokikh, T. Pestova, J.R. Lorsch, and A.G. Hinnebusch. (2007) Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo. Genes Dev. 21:1217-1230. Fekete, C.A., S.F. Mitchell, V.A. Cherkasova, D. Applefield, M.A. Algire, D. Maag, A.K. Saini, J.R. Lorsch, and A.G. Hinnebusch. (2007) N- and C-terminal residues of eIF1A have opposing effects on the fidelity of start codon selection. EMBO J. 26:1602-1614. Guntas, G., S.F Mitchell, and M. Ostermeier. (2004) A molecular switch created by in vitro recombination of nonhomologous genes. Chem. Biol. 11:1483-1487. Alexandrov, A., M. Vignali, D.J. LaCount, E. Quartley, C. de Vries, D. De Rosa, J. Babulski, S.F. Mitchell, L.W. Schoenfeld, S. Fields, W.G. Hol, M.E. Dumont, E.M. Phizicky, and E.J. Grayhack. (2004) A facile method for high-throughput co-expression of protein pairs. Mol. Cell Proteomics 3:934-938. |
