Class of 2005
lperski2@jhu.edu | Double major - B.S. Physics, B.A. Mathematics, University of Maryland Baltimore County
Research
The goal of my research is make a parts list for the loops in proteins and to use it in three ways. The first is to be able to predict the conformation of loops using their amino acid sequences and the list. Secondly, there is a lot of evidence suggesting that a good model of the unfolded state can be derived from the coil library, so another goal is generate ensembles of unfolded proteins using this list. The final goal is to learn why protein folding predictions using fragment assembly methods are so much better than ab initio simulations.
Publications
Perskie, L.L., T.O. Street and G.D. Rose. (2008) Structures, basins and energies: A deconstruction of the Protein Coil Library. Prot. Sci. 17:1151-1161.
Street, T.O., N.C. Fitzkee, L.L. Perskie, and G.D. Rose. (2007) Physical-chemical determinants of turn conformations in globular proteins. Prot. Sci. 16:1720-1727. |
